International Journal of High Risk Behaviors and Addiction

Published by: Kowsar

Impact of Needle and Syringe Program Coverage on HIV Incidence in People Who Inject Drugs

Mehdi Noroozi 1 , Alireza Noroozi 2 , 3 , Ali Mirzazadeh 4 , 5 , Ahmad Hajebi 6 , Yadoallah Mehrabi 7 , Sayed Saeed Hashemi 7 , Hamid Sharifi 5 , Seyed Ebrahim Ghoddousi 8 , Korosh Etemad 7 and Hamid Soori 9 , *
Authors Information
1 Substance Abuse and Dependence Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IR Iran
2 School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences (TUMS), Tehran, IR Iran
3 Substance Abuse Prevention and Treatment Office (SAPTO), Ministry of Health and Medical Education (MoHME), Tehran, IR Iran
4 Department of Epidemiology and Biostatics, University of California, San Francisco, CA, USA
5 Regional Knowledge Hub, and WHO Collaborating Centre for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, IR Iran
6 Mental Health Research Center, Tehran Institute of Psychiatry, Faculty of School of Behavioral Sciences and Mental Health, Iran University of Medical Sciences, Tehran, IR Iran
7 Department of Epidemiology, Safety Promotion and Injury Prevention Research Center, Shahid Beheshti University of Medical Sciences, IR Iran
8 Mental Health, Social Health and Addiction Department (MeHSHAD), Substance Abuse Prevention and Treatment Office (SAPTO), Ministry of Health and Medical Education, Tehran, IR Iran
9 Safety Promotion and Injury Prevention research center, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Article information
  • International Journal of High Risk Behaviors and Addiction: March 2017, 6 (1); e28929
  • Published Online: September 26, 2016
  • Article Type: Research Article
  • Received: March 30, 2015
  • Revised: September 14, 2015
  • Accepted: February 21, 2016
  • DOI: 10.5812/ijhrba.28929

To Cite: Noroozi M, Noroozi A, Mirzazadeh A, Hajebi A, Mehrabi Y, et al. Impact of Needle and Syringe Program Coverage on HIV Incidence in People Who Inject Drugs, Int J High Risk Behav Addict. 2017 ; 6(1):e28929. doi: 10.5812/ijhrba.28929.

Copyright © 2016, Zahedan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Result
5. Discussion
  • 1. World drug report. 2012;
  • 2. Wilson DP, Kwon A, Anderson J, Thein R, Law MG, Maher L. Return on investment 2: Evaluating the cost-effectiveness of needle and syringe programs in Australia. 2009;
  • 3. Abu-Raddad LJ, Hilmi N, Mumtaz G, Benkirane M, Akala FA, Riedner G, et al. Epidemiology of HIV infection in the Middle East and North Africa. AIDS. 2010; 24 Suppl 2-23[DOI][PubMed]
  • 4. Nasirian M, Doroudi F, Gooya MM, Sedaghat A, Haghdoost AA. Modeling of human immunodeficiency virus modes of transmission in Iran. J Res Health Sci. 2012; 12(2): 81-7[PubMed]
  • 5. Khajehkazemi R, Osooli M, Sajadi L, Karamouzian M, Sedaghat A, Fahimfar N, et al. HIV prevalence and risk behaviours among people who inject drugs in Iran: the 2010 National Surveillance Survey. Sex Transm Infect. 2013; 89 Suppl 3-32[DOI][PubMed]
  • 6. Shrestha S, Smith MW, Broman KW, Farzadegan H, Vlahov D, Strathdee SA. Multiperson use of syringes among injection drug users in a needle exchange program: a gene-based molecular epidemiologic analysis. J Acquir Immune Defic Syndr. 2006; 43(3): 335-43[DOI][PubMed]
  • 7. Mirahmadizadeh AR, Majdzadeh R, Mohammad K, Forouzanfar MH. Prevalence of HIV and hepatitis C virus infections and related behavioral determinants among injecting drug users of drop-in centers in Iran. Iran Red Crescent Med J. 2009; 11(3): 325
  • 8. Vazirian M, Nassirimanesh B, Zamani S, Ono-Kihara M, Kihara M, Ravari SM, et al. Needle and syringe sharing practices of injecting drug users participating in an outreach HIV prevention program in Tehran, Iran: a cross-sectional study. Harm Reduct J. 2005; 2: 19[DOI][PubMed]
  • 9. Noroozi M, Mirzazadeh A, Noroozi A, Mehrabi Y, Hajebi A, Zamani S, et al. Client-level coverage of needle and syringe program and high-risk injection behaviors: a case study of people who inject drugs in Kermanshah, Iran. Addict Health. 2015; 7(3-4): 164
  • 10. Zamani S, Vazirian M, Nassirimanesh B, Razzaghi EM, Ono-Kihara M, Mortazavi Ravari S, et al. Needle and syringe sharing practices among injecting drug users in Tehran: a comparison of two neighborhoods, one with and one without a needle and syringe program. AIDS Behav. 2010; 14(4): 885-90[DOI][PubMed]
  • 11. Towards universal access: scaling up priority HIV/AIDS interventions in the health sector: progress report 2010. 2010;
  • 12. Mathers BM, Degenhardt L, Ali H, Wiessing L, Hickman M, Mattick RP, et al. HIV prevention, treatment, and care services for people who inject drugs: a systematic review of global, regional, and national coverage. Lancet. 2010; 375(9719): 1014-28[DOI][PubMed]
  • 13. Strathdee SA, Patrick DM, Currie SL, Cornelisse PG, Rekart ML, Montaner JS, et al. Needle exchange is not enough: lessons from the Vancouver injecting drug use study. AIDS. 1997; 11(8)-65[PubMed]
  • 14. Wodak A, McLeod L. The role of harm reduction in controlling HIV among injecting drug users. AIDS. 2008; 22 Suppl 2-92[DOI][PubMed]
  • 15. Salazar C, Hamidreza S. Uniting the World Against AIDS. Iran (Islamic Republic of). Joint United Nations Programme on HIV, AIDS. 2006;
  • 16. Iversen J, Topp L, Wand H, Maher L. Individual-level syringe coverage among Needle and Syringe Program attendees in Australia. Drug Alcohol Depend. 2012; 122(3): 195-200[DOI][PubMed]
  • 17. Zhang L, Yap L, Xun Z, Wu Z, Wilson DP. Needle and syringe programs in Yunnan, China yield health and financial return. BMC Public Health. 2011; 11: 250[DOI][PubMed]
  • 18. Rhodes T, Hedrich D. Harm reduction: evidence, impacts and challenges. 2010;
  • 19. Mathers BM, Degenhardt L, Phillips B, Wiessing L, Hickman M, Strathdee SA, et al. Global epidemiology of injecting drug use and HIV among people who inject drugs: a systematic review. Lancet. 2008; 372(9651): 1733-45[DOI][PubMed]
  • 20. Bluthenthal RN, Ridgeway G, Schell T, Anderson R, Flynn NM, Kral AH. Examination of the association between syringe exchange program (SEP) dispensation policy and SEP client-level syringe coverage among injection drug users. Addiction. 2007; 102(4): 638-46[DOI][PubMed]
  • 21. Bluthenthal RN, Anderson R, Flynn NM, Kral AH. Higher syringe coverage is associated with lower odds of HIV risk and does not increase unsafe syringe disposal among syringe exchange program clients. Drug Alcohol Depend. 2007; 89(2-3): 214-22[DOI][PubMed]
  • 22. Patel P, Borkowf CB, Brooks JT, Lasry A, Lansky A, Mermin J. Estimating per-act HIV transmission risk: a systematic review. AIDS. 2014; 28(10): 1509-19[DOI][PubMed]
  • 23. Hudgens MG, Longini IJ, Vanichseni S, Hu DJ, Kitayaporn D, Mock PA, et al. Subtype-specific transmission probabilities for human immunodeficiency virus type 1 among injecting drug users in Bangkok, Thailand. Am J Epidemiol. 2002; 155(2): 159-68[PubMed]
  • 24. Kaplan EH, Heimer R. A model-based estimate of HIV infectivity via needle sharing. J Acquir Immune Defic Syndr. 1992; 5(11): 1116-8[PubMed]
  • 25. Abdala N, Crowe M, Tolstov Y, Heimer R. Survival of human immunodeficiency virus type 1 after rinsing injection syringes with different cleaning solutions. Subst Use Misuse. 2004; 39(4): 581-600[PubMed]
  • 26. Abdala N, Gleghorn AA, Carney JM, Heimer R. Can HIV-1-contaminated syringes be disinfected? Implications for transmission among injection drug users. J Acquir Immune Defic Syndr. 2001; 28(5): 487-94[PubMed]
  • 27. Amin-Esmaeili M, Rahimi-Movaghar A, Razaghi EM, Baghestani AR, Jafari S. Factors Correlated With Hepatitis C and B Virus Infections Among Injecting Drug Users in Tehran, IR Iran. Hepat Mon. 2012; 12(1): 23-31[DOI][PubMed]
  • 28. Jones L, Pickering L, Sumnall H, McVeigh J, Bellis MA. A review of the effectiveness and cost-effectiveness of needle and syringe programmes for injecting drug users. 2008;
  • 29. Vickerman P, Kumaranayake L, Balakireva O, Guinness L, Artyukh O, Semikop T, et al. The cost-effectiveness of expanding harm reduction activities for injecting drug users in Odessa, Ukraine. Sex Transm Dis. 2006; 33(10 Suppl)-102[DOI][PubMed]
  • 30. Vickerman P, Hickman M, Rhodes T, Watts C. Model projections on the required coverage of syringe distribution to prevent HIV epidemics among injecting drug users. J Acquir Immune Defic Syndr. 2006; 42(3): 355-61[DOI][PubMed]
  • 31. Gibson DR, Flynn NM, Perales D. Effectiveness of syringe exchange programs in reducing HIV risk behavior and HIV seroconversion among injecting drug users. AIDS. 2001; 15(11): 1329-41[PubMed]
  • 32. Schumacher JE, Fischer G, Qian HZ. Policy drives harm reduction for drug abuse and HIV/AIDS prevention in some developing countries. Drug Alcohol Depend. 2007; 91(2-3): 300-5[PubMed]
  • 33. Wodak A, Cooney A. Effectiveness of sterile needle and syringe programmes. Int J Drug Policy. 2005; 16: 31-44
  • 34. Wodak A, Cooney A. Do needle syringe programs reduce HIV infection among injecting drug users: a comprehensive review of the international evidence. Subst Use Misuse. 2006; 41(6-7): 777-813[DOI][PubMed]
  • 35. Kumaranayake L, Vickerman P, Walker D, Samoshkin S, Romantzov V, Emelyanova Z, et al. The cost-effectiveness of HIV preventive measures among injecting drug users in Svetlogorsk, Belarus. Addiction. 2004; 99(12): 1565-76[DOI][PubMed]
  • 36. Des Jarlais DC, Perlis T, Arasteh K, Hagan H, Milliken J, Braine N, et al. "Informed altruism" and "partner restriction" in the reduction of HIV infection in injecting drug users entering detoxification treatment in New York City, 1990-2001. J Acquir Immune Defic Syndr. 2004; 35(2): 158-66[PubMed]
  • 37. Monitoring the Declaration of Commitment Adopted by the United Nations General Assembly Special Session on HIV/AID. 2014;
  • 38. Kwon JA, Iversen J, Maher L, Law MG, Wilson DP. The impact of needle and syringe programs on HIV and HCV transmissions in injecting drug users in Australia: a model-based analysis. J Acquir Immune Defic Syndr. 2009; 51(4): 462-9[DOI][PubMed]
  • 39. Sarang A, Rhodes T, Platt L. Access to syringes in three Russian cities: implications for syringe distribution and coverage. Int J Drug Policy. 2008; 19 Suppl 1-36[DOI][PubMed]
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