International Journal of High Risk Behaviors and Addiction

Published by: Kowsar

Aloe vera Aqueous Extract Effect on Morphine Withdrawal Syndrome in Morphine-Dependent Female Rats

Mohammad Reza Shahraki 1 , * , Hamideh Mirshekari 2 and Azame Sabri 3
Authors Information
1 Department of Physiology, Zahedan University of Medical Sciences, Zahedan, IR Iran
2 Zahedan Health Center, Zahedan University of Medical Sciences, Zahedan, IR Iran
3 Mashhad Health Service Center, Mashhad University of Medical Sciences, Mashhad, IR Iran
Article information
  • International Journal of High Risk Behaviors and Addiction: September 01, 2014, 3 (3); e11358
  • Published Online: July 20, 2014
  • Article Type: Research Article
  • Received: June 1, 2013
  • Revised: November 12, 2013
  • Accepted: May 25, 2014
  • DOI: 10.5812/ijhrba.11358

To Cite: Shahraki M R, Mirshekari H, Sabri A. Aloe vera Aqueous Extract Effect on Morphine Withdrawal Syndrome in Morphine-Dependent Female Rats, Int J High Risk Behav Addict. 2014 ; 3(3):e11358. doi: 10.5812/ijhrba.11358.

Copyright © 2014, Zahedan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Asadi-Shahmirzadi A, Mozaffari S, Sanei Y, Baeeri M, Hajiaghaee R, Monsef-Esfahani HR, et al. Benefit of Aloe vera and Matricaria recutita mixture in rat irritable bowel syndrome: Combination of antioxidant and spasmolytic effects. Chin J Integr Med. 2012; [DOI][PubMed]
  • 2. Hajhashemi V, Ghannadi A, Heidari AH. Anti-inflammatory and wound healing activities of Aloe littoralis in rats. Res Pharm Sci. 2012; 7(2): 73-8[PubMed]
  • 3. Bhalang K, Thunyakitpisal P, Rungsirisatean N. Acemannan, a polysaccharide extracted from Aloe vera, is effective in the treatment of oral aphthous ulceration. J Altern Complement Med. 2013; 19(5): 429-34[DOI][PubMed]
  • 4. Sudarshan R, Annigeri RG, Sree Vijayabala G. Aloe vera in the treatment for oral submucous fibrosis - a preliminary study. J Oral Pathol Med. 2012; 41(10): 755-61[DOI][PubMed]
  • 5. Devaraj S, Yimam M, Brownell LA, Jialal I, Singh S, Jia Q. Effects of Aloe vera supplementation in subjects with prediabetes/metabolic syndrome. Metab Syndr Relat Disord. 2013; 11(1): 35-40[DOI][PubMed]
  • 6. Ranade AN, Wankhede SS, Ranpise NS, Mundada MS. Development of bilayer floating tablet of amoxicillin and Aloe vera gel powder for treatment of gastric ulcers. AAPS PharmSciTech. 2012; 13(4): 1518-23[DOI][PubMed]
  • 7. Bawankar R, Deepti VC, Singh P, Subashkumar R, Vivekanandhan G, Babu S. Evaluation of bioactive potential of an Aloe vera sterol extract. Phytother Res. 2013; 27(6): 864-8[DOI][PubMed]
  • 8. Dat AD, Poon F, Pham KB, Doust J. Aloe vera for treating acute and chronic wounds. Cochrane Database Syst Rev. 2012; 2[DOI][PubMed]
  • 9. Shin S, Kim S, Oh HE, Kong H, Shin E, Do SG, et al. Dietary Aloe QDM Complex Reduces Obesity-Induced Insulin Resistance and Adipogenesis in Obese Mice Fed a High-Fat Diet. Immune Netw. 2012; 12(3): 96-103[DOI][PubMed]
  • 10. Panahi Y, Sharif MR, Sharif A, Beiraghdar F, Zahiri Z, Amirchoopani G, et al. A randomized comparative trial on the therapeutic efficacy of topical aloe vera and Calendula officinalis on diaper dermatitis in children. ScientificWorldJournal. 2012; 2012: 810234[DOI][PubMed]
  • 11. Huseini HF, Kianbakht S, Hajiaghaee R, Dabaghian FH. Anti-hyperglycemic and anti-hypercholesterolemia effects of Aloe Vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Planta Med. 2012; 78(4): 311-6
  • 12. Alemy S, Karami M, Hossini E, Ebrahimzadeh MA, Majd NS. Antinociceptive activity and effect of methanol extract of Salvia limbata on withdrawal syndrome in mice. Eur Rev Med Pharmacol Sci. 2012; 16(1): 38-42[PubMed]
  • 13. Tarameshloo M, Norouzian M, Zarein-Dolab S, Dadpay M, Mohsenifar J, Gazor R. Aloe vera gel and thyroid hormone cream may improve wound healing in Wistar rats. Anat Cell Biol. 2012; 45(3): 170-7[DOI][PubMed]
  • 14. Cowan D. Oral Aloe vera as a treatment for osteoarthritis: a summary. Br J Community Nurs. 2010; 15(6): 280-2[PubMed]
  • 15. Rathor N, Mehta AK, Sharma AK, Mediratta PK, Sharma KK. Acute effect of Aloe vera gel extract on experimental models of pain. Inflammation. 2012; 35(6): 1900-3[DOI][PubMed]
  • 16. Eshghi F, Hosseinimehr SJ, Rahmani N, Khademloo M, Norozi MS, Hojati O. Effects of Aloe vera cream on posthemorrhoidectomy pain and wound healing: results of a randomized, blind, placebo-control study. J Altern Complement Med. 2010; 16(6): 647-50[DOI][PubMed]
  • 17. Kammoun M, Miladi S, Ben Ali Y, Damak M, Gargouri Y, Bezzine S. In vitro study of the PLA2 inhibition and antioxidant activities of Aloe vera leaf skin extracts. Lipids Health Dis. 2011; 10: 30[DOI][PubMed]
  • 18. Rishi P, Rampuria A, Tewari R, Koul A. Phytomodulatory potentials of Aloe vera against Salmonella OmpR-mediated inflammation. Phytother Res. 2008; 22(8): 1075-82[DOI][PubMed]
  • 19. Houshyar H, Gomez F, Manalo S, Bhargava A, Dallman MF. Intermittent morphine administration induces dependence and is a chronic stressor in rats. Neuropsychopharmacology. 2003; 28(11): 1960-72[DOI][PubMed]
  • 20. Ghannadi A, Hajhashemi V, Abrishami R. Effects of the Persian Carum copticum fruit extracts on morphine withdrawal syndrome in mice. Res Pharm Sci. 2012; 7(3): 127-31[PubMed]
  • 21. Radke AK, Holtz NA, Gewirtz JC, Carroll ME. Reduced emotional signs of opiate withdrawal in rats selectively bred for low (LoS) versus high (HiS) saccharin intake. Psychopharmacology (Berl). 2013; 227(1): 117-26[DOI][PubMed]
  • 22. Surjushe A, Vasani R, Saple DG. Aloe vera: a short review. Indian J Dermatol. 2008; 53(4): 163-6[DOI][PubMed]
  • 23. Friedman RN, Si K. Initial characterization of the effects of Aloe vera at a crayfish neuromuscular junction. Phytother Res. 1999; 13(7): 580-3[PubMed]
  • 24. Khedmat H, Karbasi A, Amini M, Aghaei A, Taheri S. Aloe vera in treatment of refractory irritable bowel syndrome: Trial on Iranian patients. J Res Med Sci. 2013; 18(8): 732[PubMed]
  • 25. Misawa E, Tanaka M, Nabeshima K, Nomaguchi K, Yamada M, Toida T, et al. Administration of dried Aloe vera gel powder reduced body fat mass in diet-induced obesity (DIO) rats. J Nutr Sci Vitaminol (Tokyo). 2012; 58(3): 195-201[PubMed]
  • 26. Doherty JM, Frantz KJ. Attenuated effects of experimenter-administered heroin in adolescent vs. adult male rats: physical withdrawal and locomotor sensitization. Psychopharmacology (Berl). 2013; 225(3): 595-604[DOI][PubMed]
  • 27. Hutter JA, Salman M, Stavinoha WB, Satsangi N, Williams RF, Streeper RT, et al. Antiinflammatory C-glucosyl chromone from Aloe barbadensis. J Nat Prod. 1996; 59(5): 541-3[DOI][PubMed]
  • 28. Halder S, Mehta AK, Mediratta PK. Aloe vera improves memory and reduces depression in mice. Nutr Neurosci. 2013; 16(6): 250-4[DOI][PubMed]
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