International Journal of High Risk Behaviors and Addiction

Published by: Kowsar

Chronic Administration of High Doses of Nandrolone Decanoate on the Pituitary-Gonadal Axis in Male Rats

Mohammad Reza Shahraki 1 , * , Hamideh Mirshekari 2 and Ahmad Reza Shahraki 3
Authors Information
1 Department of Physiology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, IR Iran
2 Zahedan Health Center, Zahedan University of Medical Sciences, Zahedan, IR Iran
3 Emam Ali Hospital, Zahedan University of Medical Sciences, Zahedan, IR Iran
Article information
  • International Journal of High Risk Behaviors and Addiction: September 01, 2015, 4 (3); e24419
  • Published Online: September 15, 2015
  • Article Type: Brief Report
  • Received: October 13, 2014
  • Revised: February 16, 2015
  • Accepted: May 6, 2015
  • DOI: 10.5812/ijhrba.24419

To Cite: Shahraki M R, Mirshekari H, Shahraki A R. Chronic Administration of High Doses of Nandrolone Decanoate on the Pituitary-Gonadal Axis in Male Rats, Int J High Risk Behav Addict. 2015 ;4(3):e24419. doi: 10.5812/ijhrba.24419.

Abstract
Copyright © 2015, Zahedan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
Acknowledgements
Footnote
References
  • 1. Hold KM, Borges CR, Wilkins DG, Rollins DE, Joseph RJ. Detection of nandrolone, testosterone, and their esters in rat and human hair samples. J Anal Toxicol. 1999; 23(6): 416-23[PubMed]
  • 2. Chawla B, Iqbal FM, Chawla MS. Nandrolone decanoate for the treatment of erythropoietin refractory anemia: a case series. Compr Ther. 2009; 35(3-4): 199-203[PubMed]
  • 3. Gascon A, Belvis JJ, Berisa F, Iglesias E, Estopinan V, Teruel JL. Nandrolone decanoate is a good alternative for the treatment of anemia in elderly male patients on hemodialysis. Geriatr Nephrol Urol. 1999; 9(2): 67-72[PubMed]
  • 4. Lindblom J, Kindlundh AM, Nyberg F, Bergstrom L, Wikberg JE. Anabolic androgenic steroid nandrolone decanoate reduces hypothalamic proopiomelanocortin mRNA levels. Brain Res. 2003; 986(1-2): 139-47[PubMed]
  • 5. Elfverson M, Johansson T, Zhou Q, Le Greves P, Nyberg F. Chronic administration of the anabolic androgenic steroid nandrolone alters neurosteroid action at the sigma-1 receptor but not at the sigma-2 or NMDA receptors. Neuropharmacology. 2011; 61(7): 1172-81[DOI][PubMed]
  • 6. do Carmo CA, Goncalves AL, Salvadori DM, Maistro EL. Nandrolone androgenic hormone presents genotoxic effects in different cells of mice. J Appl Toxicol. 2012; 32(10): 810-4[DOI][PubMed]
  • 7. Bijlsma JW, Duursma SA, Thijssen JH, Huber O. Influence of nandrolondecanoate on the pituitary-gonadal axis in males. Acta Endocrinol (Copenh). 1982; 101(1): 108-12[PubMed]
  • 8. Camargo IC, Gaspar AL, Frei F, Mesquita Sde F. [Effects of androgenic anabolic steroids on the uterus and reproductive parameters of adult female rats]. Rev Bras Ginecol Obstet. 2009; 31(9): 453-60[PubMed]
  • 9. Maravelias C, Dona A, Stefanidou M, Spiliopoulou C. Adverse effects of anabolic steroids in athletes. A constant threat. Toxicol Lett. 2005; 158(3): 167-75[DOI][PubMed]
  • 10. Kuhn CM. Anabolic steroids. Recent Prog Horm Res. 2002; 57: 411-34[PubMed]
  • 11. Alsio J, Birgner C, Bjorkblom L, Isaksson P, Bergstrom L, Schioth HB, et al. Impact of nandrolone decanoate on gene expression in endocrine systems related to the adverse effects of anabolic androgenic steroids. Basic Clin Pharmacol Toxicol. 2009; 105(5): 307-14[DOI][PubMed]
  • 12. Oda SS, El-Ashmawy IM. Adverse effects of the anabolic steroid, boldenone undecylenate, on reproductive functions of male rabbits. Int J Exp Pathol. 2012; 93(3): 172-8[DOI][PubMed]
  • 13. Shokri S, Aitken RJ, Abdolvahhabi M, Abolhasani F, Ghasemi FM, Kashani I, et al. Exercise and supraphysiological dose of nandrolone decanoate increase apoptosis in spermatogenic cells. Basic Clin Pharmacol Toxicol. 2010; 106(4): 324-30[DOI][PubMed]
  • 14. Bhasin S, Travison TG, Storer TW, Lakshman K, Kaushik M, Mazer NA, et al. Effect of testosterone supplementation with and without a dual 5alpha-reductase inhibitor on fat-free mass in men with suppressed testosterone production: a randomized controlled trial. JAMA. 2012; 307(9): 931-9[DOI][PubMed]
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