International Journal of High Risk Behaviors and Addiction

Published by: Kowsar

Effect of Moderate Exercise on Serum Interferon-Gamma and Interleukin-17 Levels in the Morphine Withdrawal Period

Ali Heidarianpour 1 , * , Majid Vahidian Rezazadeh 1 and Alireza Zamani 2
Authors Information
1 Department of Exercise Physiology, Bu-Ali Sina University, Hamadan, IR Iran
2 Professor of Immunology, Department of Immunology, School of Medicine, Hamedan University of Medical Sciences, Hamedan, IR Iran
Article information
  • International Journal of High Risk Behaviors and Addiction: June 01, 2016, 5 (2); e26907
  • Published Online: February 13, 2016
  • Article Type: Research Article
  • Received: January 12, 2015
  • Revised: April 28, 2015
  • Accepted: April 29, 2015
  • DOI: 10.5812/ijhrba.26907

To Cite: Heidarianpour A, Vahidian Rezazadeh M, Zamani A. Effect of Moderate Exercise on Serum Interferon-Gamma and Interleukin-17 Levels in the Morphine Withdrawal Period, Int J High Risk Behav Addict. 2016 ; 5(2):e26907. doi: 10.5812/ijhrba.26907.

Copyright © 2016, Zahedan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Tompkins DA, Smith MT, Mintzer MZ, Campbell CM, Strain EC. A double blind, within subject comparison of spontaneous opioid withdrawal from buprenorphine versus morphine. J Pharmacol Exp Ther. 2014; 348(2): 217-26[DOI][PubMed]
  • 2. Greeneltch KM, Kelly-Welch AE, Shi Y, Keegan AD. Chronic morphine treatment promotes specific Th2 cytokine production by murine T cells in vitro via a Fas/Fas ligand-dependent mechanism. J Immunol. 2005; 175(8): 4999-5005[PubMed]
  • 3. Arican O, Aral M, Sasmaz S, Ciragil P. Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity. Mediators Inflamm. 2005; 2005(5): 273-9[DOI][PubMed]
  • 4. Farrell PA, Joyner MJ, Caiozzo V, American College of Sports Medicine . ACSM's advanced exercise physiology. 2012;
  • 5. Febbraio MA, Pedersen BK. Muscle-derived interleukin-6: mechanisms for activation and possible biological roles. FASEB J. 2002; 16(11): 1335-47[DOI][PubMed]
  • 6. Kohara H, Kitaura H, Fujimura Y, Yoshimatsu M, Morita Y, Eguchi T, et al. IFN-gamma directly inhibits TNF-alpha-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas/Fas ligand interactions. Immunol Lett. 2011; 137(1-2): 53-61[DOI][PubMed]
  • 7. Abbas AK, Lichtman AHH., Pillai S. Cellular and Molecular Immunology: with STUDENT CONSULT Online Access. 2014;
  • 8. Cua DJ, Tato CM. Innate IL-17-producing cells: the sentinels of the immune system. Nat Rev Immunol. 2010; 10(7): 479-89[DOI][PubMed]
  • 9. Huckans M, Fuller BE, Olavarria H, Sasaki AW, Chang M, Flora KD, et al. Multi-analyte profile analysis of plasma immune proteins: altered expression of peripheral immune factors is associated with neuropsychiatric symptom severity in adults with and without chronic hepatitis C virus infection. Brain Behav. 2014; 4(2): 123-42[DOI][PubMed]
  • 10. Weaver CT, Hatton RD, Mangan PR, Harrington LE. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol. 2007; 25: 821-52[DOI][PubMed]
  • 11. Dennison L, Moss-Morris R, Chalder T. A review of psychological correlates of adjustment in patients with multiple sclerosis. Clin Psychol Rev. 2009; 29(2): 141-53[DOI][PubMed]
  • 12. Calabrese LH, Nieman DC. Exercise, immunity, and infection. J Am Osteopath Assoc. 1996; 96(3): 166-76[PubMed]
  • 13. Owen AL, Wong DP, Dunlop G, Groussard C, Kebsi W, Dellal A, et al. High Intensity Training and Salivary Immunoglobulin-a Responses in Professional Top-Level Soccer Players: Effect of Training Intensity. J Strength Cond Res. 2014; [DOI][PubMed]
  • 14. Steensberg A, Toft AD, Bruunsgaard H, Sandmand M, Halkjær-Kristensen J, Pedersen BK. Strenuous exercise decreases the percentage of type 1 T cells in the circulation. J Appl Physiol. 2001; 91(4): 1708-12[PubMed]
  • 15. Nieman DC, Pedersen BK. Exercise and immune function. Recent developments. Sports Med. 1999; 27(2): 73-80[PubMed]
  • 16. Zhao G, Zhou S, Davie A, Su Q. Effects of moderate and high intensity exercise on T1/T2 balance. Exerc Immunol Rev. 2012; 18: 98-114[PubMed]
  • 17. Shimizu K, Kimura F, Akimoto T, Akama T, Tanabe K, Nishijima T, et al. Effect of moderate exercise training on T-helper cell subpopulations in elderly people. Exerc Immunol Rev. 2008; 14: 24-37[PubMed]
  • 18. Sugama K, Suzuki K, Yoshitani K, Shiraishi K, Kometani T. IL-17, neutrophil activation and muscle damage following endurance exercise. Exerc Immunol Rev. 2012; 18: 116-27[PubMed]
  • 19. Walsh NP, Gleeson M, Pyne DB, Nieman DC, Dhabhar FS, Shephard RJ, et al. Position statement. Part two: Maintaining immune health. Exerc Immunol Rev. 2011; 17: 64-103[PubMed]
  • 20. Golzari Z, Shabkhiz F, Soudi S, Kordi MR, Hashemi SM. Combined exercise training reduces IFN-gamma and IL-17 levels in the plasma and the supernatant of peripheral blood mononuclear cells in women with multiple sclerosis. Int Immunopharmacol. 2010; 10(11): 1415-9[DOI][PubMed]
  • 21. Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, et al. Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells. Circulation. 2009; 119(10): 1424-32[DOI][PubMed]
  • 22. Institute of Laboratory Animal Resources . Guide for the Care and Use of Laboratory Animals. 1996;
  • 23. Calegari VC, Zoppi CC, Rezende LF, Silveira LR, Carneiro EM, Boschero AC. Endurance training activates AMP-activated protein kinase, increases expression of uncoupling protein 2 and reduces insulin secretion from rat pancreatic islets. J Endocrinol. 2011; 208(3): 257-64[DOI][PubMed]
  • 24. West JP, Dykstra LA, Lysle DT. Immunomodulatory effects of morphine withdrawal in the rat are time dependent and reversible by clonidine. Psychopharmacology (Berl). 1999; 146(3): 320-7[PubMed]
  • 25. Kelschenbach J, Barke RA, Roy S. Morphine withdrawal contributes to Th cell differentiation by biasing cells toward the Th2 lineage. J Immunol. 2005; 175(4): 2655-65[PubMed]
  • 26. Rahim RT, Meissler JJ, Zhang L, Adler MW, Rogers TJ, Eisenstein TK. Withdrawal from morphine in mice suppresses splenic macrophage function, cytokine production, and costimulatory molecules. J Neuroimmunol. 2003; 144(1-2): 16-27[PubMed]
  • 27. Ranjbar R, Pirayesh Shirazi Nezhad M, Eslami R. Effect of Six Weeks of Endurance Training on Levels of Interferon Gamma in Tissue of Female Mice with Cancer. Switzerland Res Park J. 2013; 102(10)
  • 28. Zar A, Ebrahim K, Hovanloo F, Amani D. Effects of An 8-Week Endurance Training Course on Changes in Interferon Gamma and Leukocyte Subsets. J Isfahan Med School. 2012; 30(185)
  • 29. White LJ, Castellano V. Exercise and brain health--implications for multiple sclerosis: Part 1--neuronal growth factors. Sports Med. 2008; 38(2): 91-100[PubMed]
  • 30. Malm C. Exercise immunology: the current state of man and mouse. Sports Med. 2004; 34(9): 555-66[PubMed]
  • 31. Wilson NJ, Boniface K, Chan JR, McKenzie BS, Blumenschein WM, Mattson JD, et al. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol. 2007; 8(9): 950-7[DOI][PubMed]
  • 32. Roy S, Ninkovic J, Banerjee S, Charboneau RG, Das S, Dutta R, et al. Opioid drug abuse and modulation of immune function: consequences in the susceptibility to opportunistic infections. J Neuroimmune Pharmacol. 2011; 6(4): 442-65[DOI][PubMed]
  • 33. Cruzat VF, Krause M, Newsholme P. Amino acid supplementation and impact on immune function in the context of exercise. J Int Soc Sports Nutr. 2014; 11(1): 61[DOI][PubMed]
  • 34. Lowder T, Dugger K, Estell K, Deshane J, Schwiebert L. Exercise increases regulatory T cell function and decreases Th2 and Th17 cytokine production in healthy and asthmatic mice. J Immunol. 2010; 184(1): 97.15
  • 35. Duzova H, Karakoc Y, Emre MH, Dogan ZY, Kilinc E. Effects of Acute Moderate and Strenuous Exercise Bouts on IL-17 Production and Inflammatory Response in Trained Rats. J Sports Sci Med. 2009; 8(2): 219-24[PubMed]
  • 36. Ishigame H, Kakuta S, Nagai T, Kadoki M, Nambu A, Komiyama Y, et al. Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity. 2009; 30(1): 108-19[DOI][PubMed]
  • 37. Fujino S, Andoh A, Bamba S, Ogawa A, Hata K, Araki Y, et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut. 2003; 52(1): 65-70[PubMed]
  • 38. Sumarac-Dumanovic M, Stevanovic D, Ljubic A, Jorga J, Simic M, Stamenkovic-Pejkovic D, et al. Increased activity of interleukin-23/interleukin-17 proinflammatory axis in obese women. Int J Obes (Lond). 2009; 33(1): 151-6[DOI][PubMed]
  • 39. Winer S, Paltser G, Chan Y, Tsui H, Engleman E, Winer D, et al. Obesity predisposes to Th17 bias. Eur J Immunol. 2009; 39(9): 2629-35[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments