International Journal of High Risk Behaviors and Addiction

Published by: Kowsar

Evaluating the Effect of the rs2229238 and the rs4845625 Interleukin 6 Receptor Gene Polymorphisms on Body Mass Index and the Risk of Type 2 Diabetes in an Iranian Study Population

Hamid Reza Galavi 1 , Ramin Saravani 2 , * , Ali Reza Alamdari 2 , Nasrin Ranjbar 2 , Elhame Damani 3 and Tooba Nakhzari Khodakhier 4
Authors Information
1 Student Scientific Research Center, Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, IR Iran
2 Cellular and Molecular Research Center, Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, IR Iran
3 Department of Health Education and Promotion, School of Public Health, Zahedan University of Medical Sciences, Zahedan, IR Iran
4 Department of Biology, Sistan and Balochestan Unviersity, Sistan and Balochestan, IR Iran
Article information
  • International Journal of High Risk Behaviors and Addiction: December 01, 2016, 5 (4); e33289
  • Published Online: September 28, 2016
  • Article Type: Research Article
  • Received: September 22, 2015
  • Revised: January 4, 2016
  • Accepted: January 12, 2016
  • DOI: 10.5812/ijhrba.33289

To Cite: Galavi H R, Saravani R, Alamdari A R, Ranjbar N, Damani E, et al. Evaluating the Effect of the rs2229238 and the rs4845625 Interleukin 6 Receptor Gene Polymorphisms on Body Mass Index and the Risk of Type 2 Diabetes in an Iranian Study Population, Int J High Risk Behav Addict. 2016 ; 5(4):e33289. doi: 10.5812/ijhrba.33289.

Copyright © 2016, Zahedan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010; 87(1): 4-14[DOI][PubMed]
  • 2. de Almeida-Pititto B, Dias ML, de Moraes AC, Ferreira SR, Franco DR, Eliaschewitz FG. Type 2 diabetes in Brazil: epidemiology and management. Diabetes Metab Syndr Obes. 2015; 8: 17-28[DOI][PubMed]
  • 3. 2015;
  • 4. Henriksen EJ, Diamond-Stanic MK, Marchionne EM. Oxidative stress and the etiology of insulin resistance and type 2 diabetes. Free Radic Biol Med. 2011; 51(5): 993-9[DOI][PubMed]
  • 5. Saravani R, Esmaeeli E, Tamendani MK, Nejad MN. Oxytocin receptor gene polymorphisms in patients with diabetes. Gene, Cell Tissue. 2015; 2(2)
  • 6. Alberti K, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation. Diabet Med. 1998; 15(7): 539-53
  • 7. Choi BC, Shi F. Risk factors for diabetes mellitus by age and sex: results of the National Population Health Survey. Diabetologia. 2001; 44(10): 1221-31[DOI][PubMed]
  • 8. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004; 27(5): 1047-53[PubMed]
  • 9. Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. 2011; 11(2): 98-107[DOI][PubMed]
  • 10. Interleukin-6 Receptor Mendelian Randomisation Analysis C, Swerdlow DI, Holmes MV, Kuchenbaecker KB, Engmann JE, Shah T, et al. The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet. 2012; 379(9822): 1214-24[DOI][PubMed]
  • 11. Sindhu S, Thomas R, Shihab P, Sriraman D, Behbehani K, Ahmad R. Obesity Is a Positive Modulator of IL-6R and IL-6 Expression in the Subcutaneous Adipose Tissue: Significance for Metabolic Inflammation. PLoS One. 2015; 10(7): 133494[DOI][PubMed]
  • 12. Ferreira RC, Freitag DF, Cutler AJ, Howson JM, Rainbow DB, Smyth DJ, et al. Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases. PLoS Genet. 2013; 9(4): 1003444[DOI][PubMed]
  • 13. De Filippo G, Rendina D, Moccia F, Rocco V, Campanozzi A. Interleukin-6, soluble interleukin-6 receptor/interleukin-6 complex and insulin resistance in obese children and adolescents. J Endocrinol Invest. 2015; 38(3): 339-43[DOI][PubMed]
  • 14. Wolford JK, Colligan PB, Gruber JD, Bogardus C. Variants in the interleukin 6 receptor gene are associated with obesity in Pima Indians. Mol Genet Metab. 2003; 80(3): 338-43[DOI][PubMed]
  • 15. Chang XW, Qin Y, Jin Z, Xi TF, Yang X, Lu ZH, et al. Interleukin-6 (IL-6) mediated the increased contraction of distal colon in streptozotocin-induced diabetes in rats via IL-6 receptor pathway. Int J Clin Exp Pathol. 2015; 8(5): 4514-24[PubMed]
  • 16. Vargas VR, Bonatto SL, Macagnan FE, Feoli AM, Alho CS, Santos ND, et al. Influence of the 48867A>C (Asp358Ala) IL6R polymorphism on response to a lifestyle modification intervention in individuals with metabolic syndrome. Genet Mol Res. 2013; 12(3): 3983-91[DOI][PubMed]
  • 17. Chu NF, Lin FH, Chin HC, Hong YJ. Association between interleukin-6 receptor gene variations and atherosclerotic lipid profiles among young adolescents in Taiwan. Lipids Health Dis. 2011; 10: 136[DOI][PubMed]
  • 18. Qi L, Rifai N, Hu FB. Interleukin-6 receptor gene, plasma C-reactive protein, and diabetes risk in women. Diabetes. 2009; 58(1): 275-8[DOI][PubMed]
  • 19. Qi L, Rifai N, Hu FB. Interleukin-6 receptor gene variations, plasma interleukin-6 levels, and type 2 diabetes in U.S. Women. Diabetes. 2007; 56(12): 3075-81[DOI][PubMed]
  • 20. Horibe H, Fujimaki T, Oguri M, Kato K, Matsuoka R, Abe S, et al. Association of a polymorphism of the interleukin 6 receptor gene with chronic kidney disease in Japanese individuals. Nephrology (Carlton). 2015; 20(4): 273-8[DOI][PubMed]
  • 21. Garrouste-Orgeas M, Troche G, Azoulay E, Caubel A, de Lassence A, Cheval C, et al. Body mass index. An additional prognostic factor in ICU patients. Intensive Care Med. 2004; 30(3): 437-43[DOI][PubMed]
  • 22. Bustamante M, Nogues X, Mellibovsky L, Agueda L, Jurado S, Caceres E, et al. Polymorphisms in the interleukin-6 receptor gene are associated with bone mineral density and body mass index in Spanish postmenopausal women. Eur J Endocrinol. 2007; 157(5): 677-84[DOI][PubMed]
  • 23. Esteve E, Villuendas G, Mallolas J, Vendrell J, Lopez-Bermejo A, Rodriguez M, et al. Polymorphisms in the interleukin-6 receptor gene are associated with body mass index and with characteristics of the metabolic syndrome. Clin Endocrinol (Oxf). 2006; 65(1): 88-91[DOI][PubMed]
  • 24. Lin FH, Chu NF, Lee CH, Hung YJ, Wu DM. Combined effect of C-reactive protein gene SNP +2147 A/G and interleukin-6 receptor gene SNP rs2229238 C/T on anthropometric characteristics among school children in Taiwan. Int J Obes (Lond). 2011; 35(4): 587-94[DOI][PubMed]
  • 25. Sharrett AR, Ballantyne CM, Coady SA, Heiss G, Sorlie PD, Catellier D, et al. Coronary heart disease prediction from lipoprotein cholesterol levels, triglycerides, lipoprotein(a), apolipoproteins A-I and B, and HDL density subfractions: The Atherosclerosis Risk in Communities (ARIC) Study. Circulation. 2001; 104(10): 1108-13[PubMed]
  • 26. Akhyani M, Ehsani AH, Robati RM, Robati AM. The lipid profile in psoriasis: a controlled study. J Eur Acad Dermatol Venereol. 2007; 21(10): 1330-2[DOI][PubMed]
  • 27. Rajasekaran S, Ravi K, Sivagnanam K, Subramanian S. Beneficial effects of aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes. Clin Exp Pharmacol Physiol. 2006; 33(3): 232-7[DOI][PubMed]
  • 28. Matsuoka R, Abe S, Tokoro F, Arai M, Noda T, Watanabe S, et al. Association of six genetic variants with myocardial infarction. Int J Mol Med. 2015; 35(5): 1451-9
  • 29. Harrison SC, Smith AJ, Jones GT, Swerdlow DI, Rampuri R, Bown MJ, et al. Interleukin-6 receptor pathways in abdominal aortic aneurysm. Eur Heart J. 2013; 34(48): 3707-16[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments