International Journal of High Risk Behaviors and Addiction

Published by: Kowsar

Association Between Family Factors and Illicit Polysubstance Use Amongst Methadone Maintenance Patients with Opioid Use Disorder

Hamnah Shahid 1 , Meha Bhatt 2 , Nitika Sanger 3 , Laura Zielinski 4 , Candice Luo 5 , Bianca Bantoto 6 , Ieta Shams 7 , Natalia Mouravska 8 , Sabrina Lue Tam 9 , Jacqueline Hudson 10 , Lehana Thabane 2 and Zainab Samaan 11 , *
Authors Information
1 Department of Arts and Science, McMaster University, Hamilton, Canada
2 Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Canada
3 Department of Medical Sciences, McMaster University, Hamilton, Canada
4 Department of Integrative Neuroscience Discovery and Study, McMaster University, Hamilton, Canada
5 Department of Health Sciences, McMaster University, Hamilton, Canada
6 Department of Integrated Science, McMaster University, Hamilton, Canada
7 Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Canada
8 Department of Hamilton Health Sciences, Hamilton, Canada
9 Department of Medicine, McMaster University, Hamilton, Canada
10 Peter Boris Centre for Addictions Research, St-Joseph’s Healthcare Hamilton, Hamilton, Canada
11 Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada
Article information
  • International Journal of High Risk Behaviors and Addiction: December 31, 2018, 7 (4); e58786
  • Published Online: July 24, 2018
  • Article Type: Research Article
  • Received: August 11, 2017
  • Revised: January 7, 2018
  • Accepted: February 21, 2018
  • DOI: 10.5812/ijhrba.58786

To Cite: Shahid H, Bhatt M, Sanger N, Zielinski L, Luo C, et al. Association Between Family Factors and Illicit Polysubstance Use Amongst Methadone Maintenance Patients with Opioid Use Disorder, Int J High Risk Behav Addict. 2018 ; 7(4):e58786. doi: 10.5812/ijhrba.58786.

Copyright © 2018, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Centre for Addiction and Mental Health. Do you know... Prescription opioids. 2003, [updated 2010]. Available from:
  • 2. Association AP. Diagnostic and Statistical Manual of Mental Disorders. 5 ed. Arlington: American Psychiatric Publishing; 2013. 991 p.
  • 3. United Nations Office on Drugs and Crime. World drug report. New York: United Nations Office on Drugs and Crime; 2015. Available from:
  • 4. Saloner B, Karthikeyan S. Changes in Substance Abuse Treatment Use Among Individuals With Opioid Use Disorders in the United States, 2004-2013. JAMA. 2015;314(14):1515-7. doi: 10.1001/jama.2015.10345. [PubMed: 26462001].
  • 5. Weiss RD, Martinez-Raga J, Hufford C. The significance of a coexisting opioid use disorder in cocaine dependence: an empirical study. Am J Drug Alcohol Abuse. 1996;22(2):173-84. [PubMed: 8727053].
  • 6. Stinson FS, Grant BF, Dawson DA, Ruan WJ, Huang B, Saha T. Comorbidity between DSM-IV alcohol and specific drug use disorders in the United States: Results from the National Epidemiologic Survey on Alcohol and Related Conditions. Drug Alcohol Depen. 2005;80(1):105-16. doi: 10.1016/j.drugalcdep.2005.03.009.
  • 7. Burns L, Teesson M. Alcohol use disorders comorbid with anxiety, depression and drug use disorders. Drug Alcohol Depen. 2002;68(3):299-307. doi: 10.1016/s0376-8716(02)00220-x.
  • 8. Joseph H, Stancliff S, Langrod J. Methadone maintenance treatment (MMT): a review of historical and clinical issues. Mt Sinai J Med. 2000;67(5-6):347-64. [PubMed: 11064485].
  • 9. Ball JC, Ross A. The effectiveness of methadone maintenance treatment. New York: Springer-Verlag; 1991. 283 p.
  • 10. Dole VP, Joseph H. Long-Term Outcome of Patients Treated with Methadone Maintenance. Ann Ny Acad Sci. 1978;311(1 Recent Develo):181-96. doi: 10.1111/j.1749-6632.1978.tb16775.x.
  • 11. Rounsaville BJ, Kosten TR, Weissman MM, Prusoff B, Pauls D, Anton SF, et al. Psychiatric disorders in relatives of probands with opiate addiction. Arch Gen Psychiatry. 1991;48(1):33-42. [PubMed: 1984760].
  • 12. Merikangas KR, Stolar M, Stevens DE, Goulet J, Preisig MA, Fenton B, et al. Familial transmission of substance use disorders. Arch Gen Psychiatry. 1998;55(11):973-9. [PubMed: 9819065].
  • 13. Boyd SJ, Plemons BW, Schwartz RP, Johnson JL, Pickens RW. The relationship between parental history and substance use severity in drug treatment patients. Am J Addict. 1999;8(1):15-23. [PubMed: 10189511].
  • 14. Coviello DM, Alterman AI, Cacciola JS, Rutherford MJ, Zanis DA. The role of family history in addiction severity and treatment response. J Subst Abuse Treat. 2004;26(1):303-13. [PubMed: 14698794].
  • 15. Samaan Z, Bawor M, Dennis BB, Plater C, Varenbut M, Daiter J, et al. Genetic influence on methadone treatment outcomes in patients undergoing methadone maintenance treatment for opioid addiction: a pilot study. Neuropsychiatr Dis Treat. 2014;10:1503-8. doi: 10.2147/NDT.S66234. [PubMed: 25187714]. [PubMed Central: PMC4149396].
  • 16. Marsden J, Gossop M, Stewart D, Best D, Farrell M, Lehmann P, et al. The Maudsley Addiction Profile (MAP): a brief instrument for assessing treatment outcome. Addiction. 1998;93(12):1857-67. [PubMed: 9926574].
  • 17. STROBE Statement. Institute of Social and Preventative Medicine-University of Bern. 2007, [cited May 9 2017]. Available from:
  • 18. Wright S. Coefficients of Inbreeding and Relationship. Am Nat. 1922;56(645):330-8. doi: 10.1086/279872.
  • 19. Van Voorhis CRW, Morgan BL. Understanding Power and Rules of Thumb for Determining Sample Sizes. Tutorial Quanti Method Psychol. 2007;3(2):43-50. doi: 10.20982/tqmp.03.2.p043.
  • 20. Stein JA, Newcomb MD, Bentler PM. An 8-year study of multiple influences on drug use and drug use consequences. J Pers Soc Psychol. 1987;53(6):1094-105. [PubMed: 3694450].
  • 21. Ahmed SW, Bush PJ, Davidson FR, Iannotti RJ. Predicting children's use and intentions to use abusable substances Paper presented at the Annual Meeting of the American Public Health Association. Anaheim, CA. 1984.
  • 22. Hawkins JD, Catalano RF, Miller JY. Risk and protective factors for alcohol and other drug problems in adolescence and early adulthood: implications for substance abuse prevention. Psychol Bull. 1992;112(1):64-105. [PubMed: 1529040].
  • 23. Dutra L, Stathopoulou G, Basden SL, Leyro TM, Powers MB, Otto MW. A meta-analytic review of psychosocial interventions for substance use disorders. Am J Psychiatry. 2008;165(2):179-87. doi: 10.1176/appi.ajp.2007.06111851. [PubMed: 18198270].
  • 24. White WL, Campbell MD, Spencer RD, Hoffman HA, Crissman B, DuPont RL. Patterns of abstinence or continued drug use among methadone maintenance patients and their relation to treatment retention. J Psychoactive Drugs. 2014;46(2):114-22. doi: 10.1080/02791072.2014.901587. [PubMed: 25052787].
  • 25. O'Farrell TJ, Fals-Stewart W. Behavioral couples therapy for alcoholism and drug abuse. J Subst Abuse Treat. 2000;18(1):51-4. doi: 10.1016/s0740-5472(99)00026-4.

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