International Journal of High Risk Behaviors and Addiction

Published by: Kowsar

Higher Frequency of Transfusion-Transmitted Virus (TTV) in HIV Patients in Comparison with Healthy Blood Donors

Mohammad Taheri 1 , Mohammad Motamedifar 1 , 2 , * , Jamal Sarvari 1 , Ramin Yaghobi 3 , Negin Nikouyan 1 , Neda Pirbonyeh 1 and Kamran Bagheri Lankarani ORCID 4
Authors Information
1 Department of Bacteriology and Virology, Shiraz University of Medical Sciences, Shiraz, IR Iran
2 Shiraz HIV/Aids Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran
3 Shiraz Transplant Research Center, Shiraz, IR Iran
4 Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, IR Iran
Article information
  • International Journal of High Risk Behaviors and Addiction: September 2017, 6 (3); e59363
  • Published Online: August 9, 2017
  • Article Type: Research Article
  • Received: September 12, 2015
  • Revised: April 10, 2016
  • Accepted: November 29, 2016
  • DOI: 10.5812/ijhrba.59363

To Cite: Taheri M, Motamedifar M, Sarvari J, Yaghobi R, Nikouyan N, et al. Higher Frequency of Transfusion-Transmitted Virus (TTV) in HIV Patients in Comparison with Healthy Blood Donors, Int J High Risk Behav Addict. 2017 ; 6(3):e59363. doi: 10.5812/ijhrba.59363.

Copyright © 2017, International Journal of High Risk Behaviors and Addiction. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Nishizawa T, Okamoto H, Konishi K, Yoshizawa H, Miyakawa Y, Mayumi M. A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology. Biochem Biophys Res Commun. 1997; 241(1): 92-7[DOI][PubMed]
  • 2. Vasilyev EV, Trofimov DY, Tonevitsky AG, Ilinsky VV, Korostin DO, Rebrikov DV. Torque Teno Virus (TTV) distribution in healthy Russian population. Virol J. 2009; 6: 134[DOI][PubMed]
  • 3. Okamoto H, Nishizawa T, Takahashi M, Tawara A, Peng Y, Kishimoto J, et al. Genomic and evolutionary characterization of TT virus (TTV) in tupaias and comparison with species-specific TTVs in humans and non-human primates. J Gen Virol. 2001; 82: 2041-50[DOI][PubMed]
  • 4. Hussain T, Manzoor S, Waheed Y, Tariq H, Hanif K. Phylogenetic analysis of Torque Teno Virus genome from Pakistani isolate and incidence of co-infection among HBV/HCV infected patients. Virol J. 2012; 9: 320[DOI][PubMed]
  • 5. Inami T, Konomi N, Arakawa Y, Abe K. High prevalence of TT virus DNA in human saliva and semen. J Clin Microbiol. 2000; 38(6): 2407-8[PubMed]
  • 6. Gallian P, Berland Y, Olmer M, Raccah D, de Micco P, Biagini P, et al. TT virus infection in French hemodialysis patients: study of prevalence and risk factors. J Clin Microbiol. 1999; 37(8): 2538-42[PubMed]
  • 7. Prescott LE, Simmonds P. Global distribution of transfusion-transmitted virus. N Engl J Med. 1998; 339(11): 776-7[DOI][PubMed]
  • 8. Spandole S, Cimponeriu D, Berca LM, Mihaescu G. Human anelloviruses: an update of molecular, epidemiological and clinical aspects. Arch Virol. 2015; 160(4): 893-908[DOI][PubMed]
  • 9. Sara A, Solhjoo K, Jahromi ARS, Yaghobi R. Study the prevalence of TT virus infection in South Iranian volunteer blood donors. Afr J Microbiol Res. 2012; 6(32): 6230-4
  • 10. Perkins EL, Stennis KB, Taylor Spriggs V, Kwegyir-Afful EA, Prather A. Is Knowledge Enough? Considering HIV/AIDS Risk Behaviors and HIV/AIDS Knowledge with African American Women. Int J High Risk Behav Addict. 2014; 3(3)[DOI][PubMed]
  • 11. Zareban I, Araban M. Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome Risk (HIV/AIDS)-Taking Behavior and HIV/AIDS Knowledge With African-American Women. Int J High Risk Behav Addict. 2015; 4(4)[DOI][PubMed]
  • 12. MacDonald DM, Scott GR, Clutterbuck D, Simmonds P. Infrequent detection of TT virus infection in intravenous drug users, prostitutes, and homosexual men. J Infect Dis. 1999; 179(3): 686-9[DOI][PubMed]
  • 13. Christensen JK, Eugen-Olsen J, S. Lrensen M , Ullum H, Gjedde SB, Pedersen BK, et al. Prevalence and prognostic significance of infection with TT virus in patients infected with human immunodeficiency virus. J Infect Dis. 2000; 181(5): 1796-9[DOI][PubMed]
  • 14. Puig-Basagoiti F, Cabana M, Guilera M, Gimenez-Barcons M, Sirera G, Tural C, et al. Prevalence and route of transmission of infection with a novel DNA virus (TTV), hepatitis C virus, and hepatitis G virus in patients infected with HIV. J Acquir Immune Defic Syndr. 2000; 23(1): 89-94[PubMed]
  • 15. Shibayama T, Masuda G, Ajisawa A, Takahashi M, Nishizawa T, Tsuda F, et al. Inverse relationship between the titre of TT virus DNA and the CD4 cell count in patients infected with HIV. AIDS. 2001; 15(5): 563-70[PubMed]
  • 16. Motamedifar M, Taheri M, Lankarani K, Gholami M. The prevalence and risk factors of hepatitis delta virus in HIV/HBV co-infected patients in Shiraz, Iran, 2012. Iran J Med Sci. 2015; 40(5): 448
  • 17. Sherman KE, Rouster SD, Feinberg J. Prevalence and genotypic variability of TTV in HIV-infected patients. Dig Dis Sci. 2001; 46(11): 2401-7[PubMed]
  • 18. Garcia-Alvarez M, Berenguer J, Alvarez E, Guzman-Fulgencio M, Cosin J, Miralles P, et al. Association of torque teno virus (TTV) and torque teno mini virus (TTMV) with liver disease among patients coinfected with human immunodeficiency virus and hepatitis C virus. Eur J Clin Microbiol Infect Dis. 2013; 32(2): 289-97[DOI][PubMed]
  • 19. Touinssi M, Gallian P, Biagini P, Attoui H, Vialettes B, Berland Y, et al. TT virus infection: prevalence of elevated viraemia and arguments for the immune control of viral load. J Clin Virol. 2001; 21(2): 135-41[PubMed]
  • 20. Reiberger T, Ferlitsch A, Sieghart W, Kreil A, Breitenecker F, Rieger A, et al. HIV-HCV co-infected patients with low CD4+ cell nadirs are at risk for faster fibrosis progression and portal hypertension. J Viral Hepat. 2010; 17(6): 400-9[DOI][PubMed]
  • 21. Thorpe J, Saeed S, Moodie EE, Klein MB, Canadian Co-infection Cohort S. Antiretroviral treatment interruption leads to progression of liver fibrosis in HIV-hepatitis C virus co-infection. AIDS. 2011; 25(7): 967-75[DOI][PubMed]
  • 22. Okamoto H, Takahashi M, Nishizawa T, Tawara A, Fukai K, Muramatsu U, et al. Genomic characterization of TT viruses (TTVs) in pigs, cats and dogs and their relatedness with species-specific TTVs in primates and tupaias. J Gen Virol. 2002; 83: 1291-7[PubMed]
  • 23. Shieh B, Chang MJ, Ko WC, Chen EJ, Wu JC, Lee CF, et al. Effects of multiple virus coinfections on disease progression in HIV-positive patients. Intervirology. 2003; 46(2): 105-13[PubMed]
  • 24. Ikeda H, Takasu M, Inoue K, Okamoto H, Miyakawa Y, Mayumi M. Infection with an unenveloped DNA virus (TTV) in patients with acute or chronic liver disease of unknown etiology and in those positive for hepatitis C virus RNA. J Hepatol. 1999; 30(2): 205-12[PubMed]
  • 25. Masia G, Ingianni A, Demelia L, Faa G, Manconi PE, Pilleri G, et al. TT virus infection in Italy: prevalence and genotypes in healthy subjects, viral liver diseases and asymptomatic infections by parenterally transmitted viruses. J Viral Hepat. 2001; 8(5): 384-90[PubMed]
  • 26. Pirouzi A, Bahmani M, Feizabadi MM, Afkari R. Molecular characterization of Torque teno virus and SEN virus co-infection with HIV in patients from Southern Iran. Rev Soc Bras Med Trop. 2014; 47(3): 275-9[PubMed]
  • 27. Maggi F, Bendinelli M. Immunobiology of the Torque teno viruses and other anelloviruses. Curr Top Microbiol Immunol. 2009; 331: 65-90[PubMed]
  • 28. Zheng MY, Lin Y, Li DJ, Ruan HB, Chen Y, Wu TT. [TTV and HPV co-infection in cervical smears of patients with cervical lesions in littoral of Zhejiang province]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2010; 24(2): 110-2[PubMed]
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