International Journal of High Risk Behaviors and Addiction

Published by: Kowsar

Torsades de Pointes on Chronic Methadone Use

Leila Hosseini 1 , 2 , Alireza Heidari-Bakavoli 3 , Najmeh Shahini 4 , 5 , 6 , Sara Mashhadinezhad 7 and Sara Hosseini 7 , *
Authors Information
1 Cardiologist, North Khorasan University of Medical Sciences, Bojnurd, IR Iran
2 Fellowship of Echocardiography, Shaheed Rajaei Cardiovascular Medical and Research Center(RCMRC), Iran University of Medical Sciences, Tehran, IR Iran
3 Cardiovascular Department, Mashhad University of Medical Sciences, Mashhad, IR Iran
4 Psychiatry and Behavioral Sciences Research Center, Ibn-e-Sina Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran
5 Student Research Committee, Mashhad University of Medical Sciences, Mashhad, IR Iran
6 Golestan Psychiatry Research Center, Golestan University of Medical Sciences, Gorgan, IR Iran
7 Cardiologist, Mashhad University of Medical Sciences, Mashhad, IR Iran
Article information
  • International Journal of High Risk Behaviors and Addiction: March 2018, 7 (1); e67762
  • Published Online: March 6, 2018
  • Article Type: Letter
  • Received: April 14, 2016
  • Revised: August 31, 2016
  • Accepted: March 15, 2017
  • DOI: 10.5812/ijhrba.67762

To Cite: Hosseini L, Heidari-Bakavoli A, Shahini N, Mashhadinezhad S, Hosseini S. Torsades de Pointes on Chronic Methadone Use, Int J High Risk Behav Addict. 2018 ; 7(1):e67762. doi: 10.5812/ijhrba.67762.

Copyright © 2018, International Journal of High Risk Behaviors and Addiction. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
  • 1. Chugh SS, Socoteanu C, Reinier K, Waltz J, Jui J, Gunson K. A community-based evaluation of sudden death associated with therapeutic levels of methadone. Am J Med. 2008;121(1):66-71. doi: 10.1016/j.amjmed.2007.10.009. [PubMed: 18187075].
  • 2. Raina S, Paydak H, Al-Lahham T, Shihabuddin BS. Methadone induced Torsades de Pointes mimicking seizures in clinical presentation. Am J Drug Alcohol Abuse. 2014;40(6):490-2. doi: 10.3109/00952990.2014.965311. [PubMed: 25321151].
  • 3. Justo D, Gal-Oz A, Paran Y, Goldin Y, Zeltser D. Methadone-associated Torsades de Pointes (polymorphic ventricular tachycardia) in opioid-dependent patients. Addiction. 2006;101(9):1333-8. doi: 10.1111/j.1360-0443.2006.01512.x. [PubMed: 16911733].
  • 4. Lipski J, Stimmel B, Donoso E. The effect of heroin and multiple drug abuse on the electrocardiogram. Am Heart J. 1973;86(5):663-8. [PubMed: 4743335].
  • 5. Krantz MJ, Kutinsky IB, Robertson AD, Mehler PS. Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes. Pharmacotherapy. 2003;23(6):802-5. [PubMed: 12820821].
  • 6. Abramson DW, Quinn DK, Stern TA. Methadone-Associated QTc Prolongation: A Case Report and Review of the Literature. Prim Care Companion J Clin Psychiatry. 2008;10(6):470-6. [PubMed: 19287558].

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