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Quantitative Study of Volumetric Changes of Cerebellum in Male Adult Rat Following Lithium Administration

AUTHORS

Zahra Heidari 1 , Hamidreza Mahmoudzadeh-Sagheb ORCID 1 , *

AUTHORS INFORMATION

1 Department of Histology, School of of Medicine, Zahedan University of Medical Sciences, Zahedan, IR Iran

How to Cite: Heidari Z, Mahmoudzadeh-Sagheb H. Quantitative Study of Volumetric Changes of Cerebellum in Male Adult Rat Following Lithium Administration, Int J High Risk Behav Addict. Online ahead of Print ; 1(2):66-70. doi: 10.5812/ijhrba.4187.

ARTICLE INFORMATION

International Journal of High Risk Behaviors and Addiction: 1 (2); 66-70
Published Online: July 24, 2012
Article Type: Research Article
Received: January 17, 2012
Accepted: June 10, 2012
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Abstract

Background: Lithium is a drug for treatment of bipolar disorder by correcting mania and reducing depressive mood swings.

Objectives: In this study, effects of Lithium on volumetric parameters of cerebellum were investigated using stereological methods.

Materials and Methods: In this experimental study, 20 sexually mature wistar male rats were selected and divided in two groups randomly (n = 10). Administration and control groups received continuously 0.1 percent Lithium carbonate solution and distilled water respectively with drinking water during a period of 12 weeks. Rats cerebellum excised and fixed in modified Lillies solution. Then tissues were dehydrated, cleared, and embedded in paraplast in random orientation, and exhaustively sectioned. Ten to twelve sections of ~ 5?m were sampled and stained from each cerebellum by systematic uniform random sampling. The whole section image projected on the table, and using Cavaliers principle point-counting was employed to estimate the volumetric parameters. Data analyzed by nonparametric statistical test of Mann-Whitney, and differences between groups less than 0.05 considered significant.

Results: There were no significant difference in terms of total volume but gray matter volume of cerebellum increased and white matter decreased in administration group significantly (P < 0.05).

Conclusions: Administration of 0.1% Lithium carbonate for a period of 12 weeks can affect cerebellar gray and white matters in rat.

Keywords

Lithium Cerebellum Bipolar Disorder

© 2012, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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